Translated anti-sense product of the Na/phosphate co-transporter (NaPi-II)
نویسندگان
چکیده
منابع مشابه
Translated anti-sense product of the Na/phosphate co-transporter (NaPi-II).
The homeostasis of Pi in marine teleosts is maintained by renal Pi secretion as well as by Pi reabsorption. A Na/Pi co-transport system belonging to the NaPi-II protein family is instrumental in tightly controlled renal Pi handling in mammals and fish. We have isolated an NaPi-II related cDNA from winter flounder. It was cloned from a female gonad cDNA library and is 624 bp long. The transcript...
متن کاملPosttranscriptional regulation of the proximal tubule NaPi-II transporter in response to PTH and dietary Pi.
The rate of proximal tubular reabsorption of phosphate (Pi) is a major determinant of Pi homeostasis. Deviations of the extracellular concentration of Piare corrected by many factors that control the activity of Na-Pi cotransport across the apical membrane. In this review, we describe the regulation of proximal tubule Pi reabsorption via one particular Na-Pi cotransporter (the type IIa cotransp...
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چکیده ندارد.
15 صفحه اولCharacterization of a cis-acting element in the renal NaPi-2 co-transporter mRNA that determines mRNA stability
Hypophosphatemia leads to an increase in Na-Pi co-transporter (NaPi-2) mRNA levels. This increase is post-transcriptional and correlates with a more stable transcript mediated by the terminal 698 nt of the NaPi-2mRNA. A 71 nt binding element was identified using renal proteins from rats fed control and low Pi diet. The binding of (–) Pi renal proteins to this transcript was increased compared t...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1998
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3320483